Tetrahedron letters

Efficient methodology for the preparation of β-aminotetralin derivatives via electrophilic amination

P Gmeiner, B Bollinger

Index: Gmeiner, Peter; Bollinger, Bernd Tetrahedron Letters, 1991 , vol. 32, # 42 p. 5927 - 5930

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Citation Number: 16

Abstract

Abstract A mild and efficient method for the construction of β-aryl amines from the corresponding α-aryl ketones is presented. The key steps of the synthesis involve an electrophilic amination by dibenzyl azodicarboxylate followed by a stereoselective LiHBEt 3 reduction. The reaction sequence is applied to the synthesis of the tricyclic ergoline analogue 4.