Biological and Pharmaceutical Bulletin

Synthesis and pharmacological activities of hydrazones, Schiff and Mannich bases of isatin derivatives.

SK Sridhar, A Ramesh

Index: Sridhar, Seshaiah Krishnan; Ramesh, Atmakuru Biological and Pharmaceutical Bulletin, 2001 , vol. 24, # 10 p. 1149 - 1152

Full Text: HTML

Citation Number: 123

Abstract

Schiff bases and phenyl hydrazone of isatins were prepared by reacting isatin and the appropriate aromatic primary amine/hydrazines. A new series of the corresponding N- mannich bases were synthesized by reacting them with formaldehyde and diphenylamine. The chemical structures were confirmed by means of their 1 H-NMR, IR spectral data and elemental analysis. The compounds were screened for analgesic, antiinflammatory and ...