Suzuki–Miyaura Cross-Coupling of Potassium Alkoxyethyltrifluoroborates: Access to Aryl/Heteroarylethyloxy Motifs

…, V Colombel, D Oehlrich, F Rombouts…

Index: Colombel, Virginie; Rombouts, Frederik; Oehlrich, Daniel; Molander, Gary A. Journal of Organic Chemistry, 2012 , vol. 77, # 6 p. 2966 - 2970

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Citation Number: 21

Abstract

The introduction of an alkoxyethyl moiety onto aromatic substructures has remained a long- standing challenge for synthetic organic chemists. The main reasons are the inherent instability of alkoxyethylmetallic species and the lack of general procedures to access them. A new method utilizing a cross-coupling strategy based on the exceptional properties of organotrifluoroborates has been developed, and the method allows an easy and efficient ...