d??Glucose as a Regioselectively Addressable Scaffold for Combinatorial Chemistry on Solid Phase

…, F Nicotra, CP Leslie, F Micheli, P Seneci…

Index: Peri, Francesco; Nicotra, Francesco; Leslie, Colin P.; Micheli, Fabrizio; Seneci, Pierfausto; Marchioro, Carla Journal of Carbohydrate Chemistry, 2003 , vol. 22, # 1 p. 57 - 71

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Citation Number: 14

Abstract

d??Glucose derivatives bearing an anomeric thiophenyl group and orthogonally protections on secondary hydroxyl groups were linked to solid supports (PS/DV polymer, tentagel resin) through an ester bond on C??6. It was investigated the possibility to remove orthogonally protecting groups and functionalize selectively the free hydroxyls groups and the anomeric carbon of sugars in solid phase.