Synthesis, cytotoxicity and topoisomerase inhibition properties of multifarious aminoalkylated indeno [1, 2-c] isoquinolin-5, 11-diones

…, N Schifano-Faux, JF Goossens, B Baldeyrou…

Index: Ahn, Gang; Schifano-Faux, Nadege; Goossens, Jean-Francois; Baldeyrou, Brigitte; Couture, Axel; Grandclaudon, Pierre; Lansiaux, Amelie; Ryckebusch, Adina Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 8 p. 2259 - 2263

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Citation Number: 7

Abstract

A number of mono-or diaminoalkylated indeno [1, 2-c] isoquinolin-5, 11-diones analogs of 1 were synthesized and evaluated for their DNA binding affinities, topoisomerase inhibition properties and antiproliferative activities against human cancer cell lines (HL60). Impact of the side chain connected to the aromatic D ring and to the N6 lactam position on the biological profile will be discussed.