Biomarkers

32P-postlabelling analysis of 1, 3-butadiene-induced DNA adducts in vivo and in vitro

C Zhao, M Koskinen, K Hemminki

Index: Zhao, Chunyan; Koskinen, Mikko; Hemminki, Kari Toxicology Letters, 1998 , vol. 102-103, p. 591 - 594

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Citation Number: 5

Abstract

Butadiene monoepoxide (BMO), epoxybutanediol (EBD) and diepoxybutane (DEB) are reactive metabolites of 1, 3-butadiene (BD), an important industrial chemical classified as a probable human carcinogen. The covalent interactions of these metabolites with DNA lead