Preparation of 2, 3, 4-Trihydroxybutylarsonic Acid: A Starting Compound for Novel Arsonolipids

MA Lala, GM Tsivgoulis, PV Ioannou

Index: Lala, Maria A.; Tsivgoulis, Gerasimos M.; Ioannou, Panayiotis V. Phosphorus, Sulfur and Silicon and the Related Elements, 2007 , vol. 182, # 12 p. 2747 - 2760

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Abstract

Possible routes for the preparation of 2, 3, 4-trihydroxybutylarsonic acid, a key compound for the synthesis of novel arsonolipids, were experimentally evaluated. The best substrate was found to be 3, 4-epoxybutane-1, 2-diol. Its reaction with alkaline sodium arsenite,“Na 3 AsO 3,” gave the arsonic acid in∼ 50% yield, as two pairs of diastereoisomers, each pair being a racemic mixture.