The substrate-and stereoselectivity of microbial reductions of 1, 4-dithiaspiro [4.5] decanones and 1, 5-dithiaspiro [5.5] undecanones

T Takemura, Y Hosoya, N Mori

Index: Takemura, Tetsuo; Hosoya, Yoshiko; Mori, Nobuo Canadian Journal of Chemistry, 1990 , vol. 68, # 4 p. 523 - 529

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Citation Number: 3

Abstract

The title spirocyclic ketones, possessing possible substitution patterns 1, 4-dithiaspiro [4.5] decan-6-one (1 a),-7-one (3 a), and-8-one (5 a), and 1, 5-dithiaspiro [5.5] undecan-7-one (2 a),-8-one (4 a), and-9-one (6 a), have been reduced with new strains of yeast (Saccharomyces cerevisiae, JCM 1819 and JCM 2214). Reductions of the prochiral ketones 1 a-4 a occur with high enantiofacial selectivity on the preparative scale (up to 99% ee). ...