Preparation and biological evaluation of 4-O-demethyldaunorubicin (carminomycin I) and of its 13-dihydro derivative.

…, A GREIN, P MASI, A SUARATO, L BERNARDI…

Index: Cassinelli; Grein; Masi; Suarato; Bernardi; Arcamone; Di Marco; Casazza; Pratesi; Soranzo Journal of Antibiotics, 1978 , vol. 31, # 3 p. 178 - 184

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Citation Number: 35

Abstract

A mutant strain of Streptomyces peucetius produced an anthracycline antibiotic whose structure has been established to be 4-O-demethyl-13-dihydrodaunorubicin (4), by applicationof spectroscopic methods and chemical degradation. A new synthesis of 4-O- demethyldaunorubicin (carminomycin I, 2) starting from daunomycinone, together with the comparison of the antitumor activity of the anthracycline glycosides 2 and 4 are also ...