The new idarubicin analogues (12 and 13) with a glucose or galactoseas as a glycone were synthesized from daunomycin (2).(+)-4-Demethoxydaunomycinone (6) obtained from reaction of 2with AlCl3 was converted to 4-trifluoromethanesulfonyl daunomycinone (7) through reaction with trifluoromethanesulfonic anhydride. The treatment of 7 with 1, 1-bis- (diphenylphospino) ferrocene/Pd (OAc) 2 in triethylamine/formic acid/dioxane provided ...
