Synthesis of the dopamine D 2/D 3 receptor agonist (+)-PHNO via supercritical fluid chromatography: preliminary PET imaging study with [3-11 C]-(+) PHNO

…, MD Normandin, AA Bonab, G El Fakhri, N Vasdev

Index: Shoup, Timothy M.; McCauley, John P.; Lee Jr., David F.; Chen, Rui; Normandin, Marc D.; Bonab, Ali A.; El Fakhri, Georges; Vasdev, Neil Tetrahedron Letters, 2014 , vol. 55, # 3 p. 682 - 685

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Citation Number: 3

Abstract

Abstract Carbon-11 labeled (+)-4-[1-11 C] propyl-3, 4, 4a, 5, 6, 10b-hexahydro-2H-naphtho [1, 2-b][1, 4] oxazin-9-ol ([1-11 C]-(+)-PHNO) is a dopamine D 3-preferring agonist radiopharmaceutical used for medical imaging by positron emission tomography (PET). We report the synthesis of (+)-PHNO using supercritical fluid chromatography for enantiomeric resolution of its norpropyl derivative, HNO, followed by propylation.(+)-HNO was used to ...