Tetrahedron

Synthesis of substituted 3, 4-dihydro-2H-pyrido [3, 2-b][1, 4] oxazine as new scaffolds for potential bioactive compounds

…, I Sánchez, A Sabatié, V Bénéteau, G Guillaumet…

Index: Henry; Sanchez; Sabatie; Beneteau; Guillaumet; Pujol Tetrahedron, 2006 , vol. 62, # 10 p. 2405 - 2412

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Citation Number: 14

Abstract

The title compounds having different substituents on the heterocyclic framework were prepared by several methods from 2-acetamido-3-hydroxypyridine. The condensation of 2- protected-amino-3-hydroxypyridine with 2-chloroacrylonitrile or ethyl 2, 3- dibromopropionate provided in several cases two isomeric pyrido-oxazines. Whereas the reaction of 2-acetamido-3-hydroxypyridine with methyl 2, 3-dibromopropionate or with α- ...