Tetrahedron

Active methylene compounds in a very effective approach to 3-substituted isobenzofuranones through tandem aldol/lactonization reactions

A Di Mola, G Croce, V More, P De Caprariis, R Filosa…

Index: Di Mola, Antonia; Croce, Gianluca; More, Vijaykumar; De Caprariis, Paolo; Filosa, Rosanna; Massa, Antonio Tetrahedron, 2012 , vol. 68, # 31 p. 6146 - 6151

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Citation Number: 7

Abstract

In this article we describe a new accessible methodology for the synthesis of isobenzofuran- 1 (3H)-ones. In this process we exploited an effective, economic, useful and environmentally benign K2CO3 catalyzed, solvent-free one-pot tandem aldol-lactonization reaction between active methylene compounds and methyl 2-carboxy benzaldehyde. A particularly simple work-up and purification procedure are additional advantages addressed to a general ...