Synthesis of Oxazoles through Copper??Mediated Aerobic Oxidative Dehydrogenative Annulation and Oxygenation of Aldehydes and Amines

Z Xu, C Zhang, N Jiao

Index: Xu, Zejun; Zhang, Chun; Jiao, Ning Angewandte Chemie - International Edition, 2012 , vol. 51, # 45 p. 11367 - 11370 Angew. Chem.

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Citation Number: 53

Abstract

Oxazoles with their 2 and 5 positions substituted with aryl or alkyl groups are regarded as privileged heterocyclic motifs in numerous pharmacologically active synthetic molecules.[1] They are also widespread in bioactive natural products.[2] Subsequently, a lot of new methods have been developed to form oxazoles.[3–6] Among these methods, the intramolecular cyclization of acyclic precursors,[3] the oxidative coupling of amines and ...