e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Pseudobase formation in 2-methylpapaverinium cations and their biotransformation by enzymes of rat liver homogenates in vitro

D Walterová, V Preininger, L Dolejš…

Index: Walterova; Preininger; Dolejs; et al. Collection of Czechoslovak Chemical Communications, 1980 , vol. 45, # 3 p. 956 - 965

Full Text: HTML

Citation Number: 4

Abstract

Abstract 2-Methylpapaverinium iodide (I), 2'-hydroxymethyl-2-methylpapaverinium iodide (IX), and 2-methyl-3, 4-dihydropapaverinium iodide (X. CH 3 I) form pseudobase by addition of hydroxide ions to the C (1)= N (+) bond. 2'-Hydroxymethyl-2-methyl-3, 4- dihydropapaverinium iodide (XV) and 2'-hydroxymethyl-2-methyl-9-oxo-3, 4- dihydropapaverinium iodide (XVI) react with hydroxide ions in aqueous medium under ...

Papaverine Structure

~%

1-Oxo-2-methyl-6,7-dimethoxy-1,2-dihydroisoquinoline Structure

1-Oxo-2-methyl-...

1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxyisoquinoline Structure

1-[(3,4-Dimetho...

~%

1-Oxo-2-methyl-6,7-dimethoxy-1,2-dihydroisoquinoline Structure

1-Oxo-2-methyl-...

1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydroisoquinoline iodide Structure

1-[(3,4-dimetho...

~%

1(2H)-Isoquinolinone,3,4-dihydro-6,7-dimethoxy-2-methyl- Structure

1(2H)-Isoquinol...

1-Oxo-2-methyl-6,7-dimethoxy-1,2-dihydroisoquinoline Structure

1-Oxo-2-methyl-...

Methanone,(6,7-dimethoxy-1-isoquinolinyl)(3,4-dimethoxyphenyl)- Structure

Methanone,(6,7-...

Detail

Isoquinolinium,1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-, iodide (1:1) Structure

Isoquinolinium,...

~%

1-Oxo-2-methyl-6,7-dimethoxy-1,2-dihydroisoquinoline Structure

1-Oxo-2-methyl-...

Papaverine Structure

veratraldehyde Structure

Detail

1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxyisoquinoline Structure

1-[(3,4-Dimetho...

~%

1(2H)-Isoquinolinone,3,4-dihydro-6,7-dimethoxy-2-methyl- Structure

1(2H)-Isoquinol...

2'-hydroxymethyl-3,4-dihydropapaverine Structure

2'-hydroxymethy...

~%

1(2H)-Isoquinolinone,3,4-dihydro-6,7-dimethoxy-2-methyl- Structure

1(2H)-Isoquinol...

2'-hydroxymethyl-9-oxo-3,4-dihydropapaverine Structure

2'-hydroxymethy...

~%

1(2H)-Isoquinolinone,3,4-dihydro-6,7-dimethoxy-2-methyl- Structure

1(2H)-Isoquinol...

2'-hydroxymethyl-2-methyl-9-oxo-3,4-dihydropapaverinium iodide Structure

2'-hydroxymethy...

~%

1(2H)-Isoquinolinone,3,4-dihydro-6,7-dimethoxy-2-methyl- Structure

1(2H)-Isoquinol...

2'-hydroxymethyl-2-methyl-3,4-dihydropapaverinium iodide Structure

2'-hydroxymethy...

~%

1(3H)-Isobenzofuranone,5,6-dimethoxy- Structure

1(3H)-Isobenzof...

1(2H)-Isoquinolinone,3,4-dihydro-6,7-dimethoxy-2-methyl- Structure

1(2H)-Isoquinol...

1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydroisoquinoline iodide Structure

1-[(3,4-dimetho...

~%

1(2H)-Isoquinolinone,3,4-dihydro-6,7-dimethoxy-2-methyl- Structure

1(2H)-Isoquinol...

1-Oxo-2-methyl-6,7-dimethoxy-1,2-dihydroisoquinoline Structure

1-Oxo-2-methyl-...

Methanone,(6,7-dimethoxy-1-isoquinolinyl)(3,4-dimethoxyphenyl)- Structure

Methanone,(6,7-...

Detail

2'-hydroxymethyl-3,4-dihydropapaverine Structure

2'-hydroxymethy...

~%

1(3H)-Isobenzofuranone,5,6-dimethoxy- Structure

1(3H)-Isobenzof...

1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxyisoquinoline Structure

1-[(3,4-Dimetho...

~%

1(3H)-Isobenzofuranone,5,6-dimethoxy- Structure

1(3H)-Isobenzof...

2'-hydroxymethyl-2-methyl-3,4-dihydropapaverinium iodide Structure

2'-hydroxymethy...

~%

1(3H)-Isobenzofuranone,5,6-dimethoxy- Structure

1(3H)-Isobenzof...

1(2H)-Isoquinolinone,3,4-dihydro-6,7-dimethoxy-2-methyl- Structure

1(2H)-Isoquinol...

coralyne Structure

~%

2-[6,7-Dimethoxy-1-isoquinolyl)methyl]-4,5-dimethoxyacetophenone Structure

2-[6,7-Dimethox...

1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydroisoquinoline iodide Structure

1-[(3,4-dimetho...

~%

1(2H)-Isoquinolinone,3,4-dihydro-6,7-dimethoxy-2-methyl- Structure

1(2H)-Isoquinol...

1-Oxo-2-methyl-6,7-dimethoxy-1,2-dihydroisoquinoline Structure

1-Oxo-2-methyl-...

Methanone,(6,7-dimethoxy-1-isoquinolinyl)(3,4-dimethoxyphenyl)- Structure

Methanone,(6,7-...

Detail

Hydroxylaudanosin Structure

Hydroxylaudanosin

~%

1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydroisoquinoline iodide Structure

1-[(3,4-dimetho...

Facile Route to 1, 3-Diazaheterocycle-Fused [1, 2 b] Isoquin...

[Lee, Albert, W. M.; Chan, Wing Hong; Chan, Eddy T. T. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 3 p. 309 - 310]

Facile Route to 1, 3-Diazaheterocycle-Fused [1, 2 b] Isoquin...

[Lee, Albert, W. M.; Chan, Wing Hong; Chan, Eddy T. T. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 3 p. 309 - 310]

Facile Route to 1, 3-Diazaheterocycle-Fused [1, 2 b] Isoquin...

[Lee, Albert, W. M.; Chan, Wing Hong; Chan, Eddy T. T. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 3 p. 309 - 310]

Facile Route to 1, 3-Diazaheterocycle-Fused [1, 2 b] Isoquin...

[Lee, Albert, W. M.; Chan, Wing Hong; Chan, Eddy T. T. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 3 p. 309 - 310]

Fragmentation of nitro (bromo)-substituted methylpapaveriniu...

[Lapa; Tolkachev Pharmaceutical Chemistry Journal, 1999 , vol. 33, # 7 p. 377 - 378]