Practical Synthesis of (1 s, 4 s)-4-(Methylamino)-1′ H-spiro [cyclohexane-1, 3′-furo [3, 4-c] pyridin]-1′-one

…, PD de Koning, SPA Dubant, D Fengas…

Index: Bish, Gerwyn; De Koning, Pieter D.; Dubant, Stephane P. A.; Fengas, David; Fray, M. Jonathan Organic Process Research and Development, 2010 , vol. 14, # 5 p. 1269 - 1271

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Abstract

A practical and scalable process for the preparation of (1 s, 4 s)-4-(methylamino)-1′ H-spiro [cyclohexane-1, 3′-furo [3, 4-c] pyridin]-1′-one 2a, a highly functionalized and potentially useful building block for pharmaceutical research is described. The material is prepared via an efficient two-step sequence from readily available materials and is isolated as a single diastereomer in high chemical purity.