Synthesis of 11??cis??Retinoids by Hydrosilylation–Protodesilylation of an 11, 12??Didehydro Precursor: Easy Access to 11??and 12??Mono??and 11, 12?? …

J Bergueiro, J Montenegro, C Saá…

Index: Bergueiro, Julian; Montenegro, Javier; Saa, Carlos; Lopez, Susana Chemistry - A European Journal, 2012 , vol. 18, # 44 p. 14100 - 14107

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Citation Number: 4

Abstract

Abstract An expeditious, highly efficient approach to 11-cis-retinoids was achieved by semihydrogenation of a readily available 11-yne precursor through a hydrosilylation– protodesilylation protocol. The complete chemo-, regio-, and syn-stereoselectivity of the method also allowed direct access to 11-and 12-monodeutero-, and 11, 12-dideutero-11-cis- retinoids. The analogous trans series was not accessible by this route, and was ...