Unexpected enhancement of thrombin inhibitor potency with o-aminoalkylbenzylamides in the P1 position

KE Rittle, JC Barrow, KJ Cutrona, KL Glass…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 20 p. 3477 - 3482

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Citation Number: 27

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... a Department of Medicinal Chemistry, Merck Research ... b Department of Biological Chemistry, Merck Research Laboratories, West Point, PA 19486, USA; c Department of Structural Biology, Merck Research Laboratories, West Point, PA ...

Syntheses of quadruply two-and three-atom, aza-bridged, cofa...

[Bookser, Brett C.; Bruice, Thomas C. Journal of the American Chemical Society, 1991 , vol. 113, # 11 p. 4208 - 4218]

An Efficient Hydrogenation of Dinitrile to Aminonitrile in S...

[Chatterjee, Maya; Sato, Masahiro; Kawanami, Hajime; Yokoyama, Toshirou; Suzuki, Toshishige; Ishizaka, Takayuki Advanced Synthesis and Catalysis, 2010 , vol. 352, # 14-15 p. 2394 - 2398]

One-Pot Primary Aminomethylation of Aryl and Heteroaryl Hali...

[Organic Letters, , vol. 14, # 11 p. 2818 - 2821]