Tetrahedron letters

Synthesis of aminopyridines from 2-fluoropyridine and lithium amides

…, AR Hernández, S Gamsey, CT Goralski, B Singaram

Index: Pasumansky, Lubov; Hernandez, Armando R.; Gamsey, Soya; Goralski, Christian T.; Singaram, Bakthan Tetrahedron Letters, 2004 , vol. 45, # 34 p. 6417 - 6420

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Citation Number: 23

Abstract

Lithium amides promote the amination of 2-fluoropyridine under mild reaction conditions, providing 2-aminopyridines in good yields and purity. Treatment of 2-fluoropyridine with 1equiv of lithium amide at room temperature affords complete conversion after 2h. To our knowledge, this is the first study of lithium amide-promoted amination of fluoropyridines that are not further activated by electron-withdrawing groups.