Hydroxamic acids as a novel family of serine racemase inhibitors: mechanistic analysis reveals different modes of interaction with the pyridoxal-5′-phosphate …

HE Hoffman, J Jirásková, P Cígler…

Index: Journal of Medicinal Chemistry, , vol. 52, # 19 p. 6032 - 6041

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Citation Number: 24

Abstract

... Journal of Medicinal Chemistry. ... a common transition state, the external aldimine, identification of active-site directed inhibitors with high specificity is a particular challenge.(6) Nevertheless, several PLP-dependent enzymes have been recognized as pharmaceutical targets, as ...