Pyrrole-2-carboxylic Acid as a Ligand for the Cu-Catalyzed Reactions of Primary Anilines with Aryl Halides

…, KW Anderson, SL Buchwald

Index: Altman, Ryan A.; Shafir, Alexandr; Choi, Alice; Lichtor, Phillip A.; Buchwald, Stephen L. Journal of Organic Chemistry, 2008 , vol. 73, # 1 p. 284 - 286

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Citation Number: 48

Abstract

Pyrrole 2-carboxylic acid (L5) was found to be an effective ligand for the Cu-catalyzed monoarylation of anilines with aryl iodides and bromides. Under the reported conditions (10% CuI/20% L5/DMSO/K3PO4/80− 100° C/20− 24 h), a variety of useful functional groups were tolerated, and moderate to good yields of the diaryl amine products were obtained.