Zn (II) complex for selective and rapid scission of protein backbone

M Yashiro, Y Kawakami, J Taya, S Arai…

Index: Yashiro, Morio; Kawakami, Yukiko; Taya, Jun-Ichi; Arai, Suguru; Fujii, Yuki Chemical Communications, 2009 , # 12 p. 1544 - 1546

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Citation Number: 6

Abstract

A ZnII complex with an aldehyde group hydrolyzed porcine pancreatic elastase under mild conditions, pH 8.0, 50° C, by the Schiff base formation between the ZnII complex and the NH2 group in the protein, suggesting that a ZnII compound can be active toward peptide hydrolysis when it strongly binds to the substrate.