Syntheses of structurally-simplified and fluorescently-labeled neovibsanin derivatives and analysis of their neurite outgrowth activity in PC12 cells

H Imagawa, H Saijo, H Yamaguchi, K Maekawa…

Index: Imagawa, Hiroshi; Saijo, Hayato; Yamaguchi, Hitomi; Maekawa, Ken; Kurisaki, Takahiro; Yamamoto, Hirofumi; Nishizawa, Mugio; Oda, Masataka; Kabura, Michiko; Nagahama, Masahiro; Sakurai, Jun; Kubo, Miwa; Nakai, Megumi; Makino, Kosho; Ogata, Mitsuko; Takahashi, Hironobu; Fukuyama, Yoshiyasu Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 2089 - 2093

Full Text: HTML

Citation Number: 13

Abstract

The syntheses of several neovibsanin derivatives were carried out in order to elucidate the simple structure required for displaying neurite outgrowth activity. In addition, a fluorescent probe molecule was synthesized and the analysis of its behavior in the PC12 cell line showed that the neovibsanins accumulate on the outer edge of the cell at the site of formation of prominences.