Kinetic and dynamic kinetic resolution of secondary alcohols with ionic-surfactant-coated Burkholderia cepacia lipase: substrate scope and enantioselectivity

…, Y Oh, YK Choi, E Choi, J Park, MJ Kim

Index: Choi, Jun Ho; Choi, Yoon Kyung; Kim, Yu Hwan; Park, Eun Sil; Kim, Eun Jung; Kim, Mahn-Joo; Park, Jaiwook Journal of Organic Chemistry, 2004 , vol. 69, # 6 p. 1972 - 1977

Full Text: HTML

Citation Number: 24

Abstract

Forty-four different secondary alcohols, which can be classified into several types (II-IX), were tested as the substrates of ionic surfactant-coated Burkholderia cepacia lipase (ISCBCL) to see its substrate scope and enantioselectivity in kinetic and dynamic kinetic resolution (KR and DKR). They include 6 boron-containing alcohols, 24 chiral propargyl alcohols, and 14 diarylmethanols. The results from the studies on KR indicate that ISCBCL ...