Discovery of 5-substituted pyrrolo [2, 3-d] pyrimidine antifolates as dual-acting inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4- …

S Mitchell-Ryan, Y Wang, S Raghavan…

Index: Journal of Medicinal Chemistry, , vol. 56, # 24 p. 10016 - 10032

Full Text: HTML

Citation Number: 8

Abstract

... Journal of Medicinal ... State University School of Medicine, Detroit, Michigan 48201, United States. ‡ Division of Medicinal Chemistry, Graduate School ... Michigan 48201, United States. ∥ Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan ...

 Related Synthetic Route
N/A Structure

151864-75-4

N/A

~%

4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid Structure

137281-39-1

4-[2-(2-Amino-4...

ethyl 4-(3-formylpropyl)benzoate Structure

72313-37-2

ethyl 4-(3-form...

~%

4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid Structure

137281-39-1

4-[2-(2-Amino-4...

ethyl 4-(3-bromo-4-oxobutyl)benzoate Structure

927897-33-4

ethyl 4-(3-brom...

~%

4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid Structure

137281-39-1

4-[2-(2-Amino-4...

ethyl 4-(3-formylpropyl)benzoate Structure

72313-37-2

ethyl 4-(3-form...

~%

PEMETREXED DIETHYL ESTER (L-GLUTAMIC ACID, N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-, 1,5-DIETHYL ESTER ) Structure

146943-43-3

PEMETREXED DIET...

ethyl 4-(3-bromo-4-oxobutyl)benzoate Structure

927897-33-4

ethyl 4-(3-brom...

~%

PEMETREXED DIETHYL ESTER (L-GLUTAMIC ACID, N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-, 1,5-DIETHYL ESTER ) Structure

146943-43-3

PEMETREXED DIET...

N/A Structure

151864-75-4

N/A

~%

PEMETREXED DIETHYL ESTER (L-GLUTAMIC ACID, N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-, 1,5-DIETHYL ESTER ) Structure

146943-43-3

PEMETREXED DIET...


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