e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

The Journal of organic chemistry

A new and efficient synthesis of pyrrolo [2, 3-d] pyrimidine anticancer agents: alimta (LY231514, MTA), homo-alimta, TNP-351, and some aryl 5-substituted pyrrolo [2, …

EC Taylor, B Liu

Index: Journal of Organic Chemistry, , vol. 68, # 26 p. 9938 - 9947

Full Text: HTML

Citation Number: 49

Abstract

... The Journal of Organic Chemistry. ... of Chemistry, Princeton University, Princeton, New Jersey 08544. J. Org. Chem. , 2003, 68 (26), pp 9938–9947. DOI: 10.1021/jo030248h. Publication Date (Web): November 22, 2003. Copyright © 2003 American Chemical Society. ...

3-(4-Carboethoxy)phenyl propanal Structure

3-(4-Carboethox...

~%

4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid Structure

4-[2-(2-Amino-4...

4-(3-hydroxy-4-nitrobutyl)benzoic acid ethyl ester Structure

4-(3-hydroxy-4-...

~%

4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid Structure

4-[2-(2-Amino-4...

3-(4-Carboethoxy)phenyl propanal Structure

3-(4-Carboethox...

~%

PEMETREXED DIETHYL ESTER (L-GLUTAMIC ACID, N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-, 1,5-DIETHYL ESTER ) Structure

PEMETREXED DIET...

4-(3-hydroxy-4-nitrobutyl)benzoic acid ethyl ester Structure

4-(3-hydroxy-4-...

~%

PEMETREXED DIETHYL ESTER (L-GLUTAMIC ACID, N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-, 1,5-DIETHYL ESTER ) Structure

PEMETREXED DIET...

4-[3-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-4-nitrobutyl]benzoic acid ethyl ester Structure

4-[3-(2,4-diami...

~%

PEMETREXED DIETHYL ESTER (L-GLUTAMIC ACID, N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-, 1,5-DIETHYL ESTER ) Structure

PEMETREXED DIET...

2-nitro-1-(3'-chlorophenyl)ethanol Structure

2-nitro-1-(3'-c...

~%

1-chloro-3-(2-nitrovinyl)benzene Structure

1-chloro-3-(2-n...

3-Chlorobenzaldehyde Structure

3-Chlorobenzaldehyde

~%

1-chloro-3-(2-nitrovinyl)benzene Structure

1-chloro-3-(2-n...

A novel synthetic approach to pyrrolo [2, 3-d] pyrimidine an...

[Journal of Organic Chemistry, , vol. 58, # 7 p. 1696 - 1701]

A novel synthetic approach to pyrrolo [2, 3-d] pyrimidine an...

[Journal of Organic Chemistry, , vol. 58, # 7 p. 1696 - 1701]

Discovery of 5-substituted pyrrolo [2, 3-d] pyrimidine antif...

[Journal of Medicinal Chemistry, , vol. 56, # 24 p. 10016 - 10032]

A simple and concise synthesis of LY231514 (MTA)

[Tetrahedron Letters, , vol. 40, # 21 p. 4023 - 4026]

A novel synthetic approach to pyrrolo [2, 3-d] pyrimidine an...

[Journal of Organic Chemistry, , vol. 58, # 7 p. 1696 - 1701]