Antitubercular, antifungal, and antibacterial activity in vitro of 1-phenethylamino-1, 2, 3, 4-tetrahydrocarbazoles

TV Akalaeva, LY Amel'kin, OV Baklanova…

Index: Akalaeva, T. V.; Amel'kin, L. Yu.; Baklanova, O. V.; Bokanov, A. I.; Ivanov, P. Yu.; et al. Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 11 p. 826 - 829 Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 11 p. 46 - 48

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Abstract

The reduction of nitrile XXI to amine was described in [9]; the hydrogenation of amine XIX has not been described in the literature. Ill [7], amine XX was obtained by hydrogenation of nitrile XXI over Raney Ni (100 atm., 60~ We carried out the transformation of amine XIX into cyclohexylamine XX under milder conditions (15 atm, 20~ and with complete conversion (according to GLC data). The refractive index of the amine~ obtained (nD 2~ 1.4646 was ...