Rapid optimization of the hydrolysis of N'-trifluoroacetyl-S-tert-leucine-N-methylamide using high-throughput chemical development techniques

VW Rosso, JL Pazdan, JJ Venit

Index: Organic Process Research and Development, , vol. 5, # 3 p. 294 - 298

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Citation Number: 16

Abstract

... as design of experiments 2 (DOE), and high-throughput synthetic techniques that allow process chemists to ... us to quickly develop the scientific understanding necessary for the implementation of processes at pilot ... organic, potassium tert butoxide, 48.6, 2.5, x, 4.9, 3.8, 3.1, 2.1, 10.8. ...