Tetrahedron Letters

Facile ring-closure cyclization of arenes by nucleophilic C-alkylation reaction in ionic liquid

DJ Hong, DW Kim, DY Chi

Index: Hong, Dong Jin; Kim, Dong Wook; Chi, Dae Yoon Tetrahedron Letters, 2010 , vol. 51, # 1 p. 54 - 56

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Citation Number: 6

Abstract

A novel synthetic method using an ionic liquid (IL) for a six-membered ring-closure cyclization is described. The ring-closure cyclization by nucleophilic C-alkylation was achieved with various halo-and alkanesulfonyloxyalkyl aromatic compounds in high yields with minimal byproducts using ILs as the reaction media in the absence of any catalyst. For example, the cyclization of 2-(3-methanesulfonyloxy-propoxy) naphthalene (1a) to 2, 3- ...