Synthesis and hypotensive activity of benzopyran derivatives.

M SHIRATSUCHI, K KAWAMURA, T AKASHI…

Index: Shiratsuchi; Kawamura; Akashi; Fujii; Ishihama; Uchida Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 2 p. 632 - 641

Full Text: HTML

Citation Number: 22

Abstract

A series of dihydrobenzopyranyloxypropanolamines and dihydrobenzopyranylethanolamines containing a nitroxy moiety was synthesized. The cardiovascular effects of these compounds were investigated in anesthetized dogs. Some of the compounds exhibited hypotensive activity in combination with β-adrenergic blocking and vasodilating action. The structure-activity relationships are discussed.

 Related Synthetic Route
8-METHOXYCHROMAN-3-OL Structure

91520-01-3

8-METHOXYCHROMA...

~87%

CHROMAN-3,8-DIOL Structure

81486-17-1

CHROMAN-3,8-DIOL

(2-methoxy-6-prop-2-enylphenyl) acetate Structure

2173-78-6

(2-methoxy-6-pr...

~%

CHROMAN-3,8-DIOL Structure

81486-17-1

CHROMAN-3,8-DIOL

(8-methoxy-3,4-dihydro-2H-chromen-3-yl) acetate Structure

91520-04-6

(8-methoxy-3,4-...

~%

CHROMAN-3,8-DIOL Structure

81486-17-1

CHROMAN-3,8-DIOL

[2-methoxy-6-(oxiran-2-ylmethyl)phenyl] acetate Structure

91520-02-4

[2-methoxy-6-(o...

~%

CHROMAN-3,8-DIOL Structure

81486-17-1

CHROMAN-3,8-DIOL

2-(2-acetoxy-3-chloro)propyl-6-methoxyphenol Structure

91520-03-5

2-(2-acetoxy-3-...

~%

CHROMAN-3,8-DIOL Structure

81486-17-1

CHROMAN-3,8-DIOL

7-methoxy-2H-1-Benzopyran Structure

18385-89-2

7-methoxy-2H-1-...

~%

2H-1-BENZOPYRAN, 3,4-DIHYDRO-7-METHOXY- Structure

3875-77-2

2H-1-BENZOPYRAN...

2',3'-DIHYDROXYACETOPHENONE Structure

13494-10-5

2',3'-DIHYDROXY...

Diethyloxalate Structure

95-92-1

Diethyloxalate

~%

ethyl 8-hydroxy-4-oxochromene-2-carboxylate Structure

53873-72-6

ethyl 8-hydroxy...

2H-1-BENZOPYRAN, 3,4-DIHYDRO-7-METHOXY- Structure

3875-77-2

2H-1-BENZOPYRAN...

~%

Chroman-7-ol Structure

57052-72-9

Chroman-7-ol

7-methoxy-2H-1-Benzopyran Structure

18385-89-2

7-methoxy-2H-1-...

~%

Chroman-7-ol Structure

57052-72-9

Chroman-7-ol

8-methoxy-2h-chromene-3-carboxylic acid Structure

57543-59-6

8-methoxy-2h-ch...

~36%

8-Methoxy-chroman-3-carboxylic acid Structure

108088-19-3

8-Methoxy-chrom...

(2-methoxy-6-prop-2-enylphenyl) acetate Structure

2173-78-6

(2-methoxy-6-pr...

~%

8-METHOXYCHROMAN-3-OL Structure

91520-01-3

8-METHOXYCHROMA...

[2-methoxy-6-(oxiran-2-ylmethyl)phenyl] acetate Structure

91520-02-4

[2-methoxy-6-(o...

~%

8-METHOXYCHROMAN-3-OL Structure

91520-01-3

8-METHOXYCHROMA...

2-(2-acetoxy-3-chloro)propyl-6-methoxyphenol Structure

91520-03-5

2-(2-acetoxy-3-...

~%

8-METHOXYCHROMAN-3-OL Structure

91520-01-3

8-METHOXYCHROMA...

(2-methoxy-6-prop-2-enylphenyl) acetate Structure

2173-78-6

(2-methoxy-6-pr...

~%

(8-methoxy-3,4-dihydro-2H-chromen-3-yl) acetate Structure

91520-04-6

(8-methoxy-3,4-...

2-(2-acetoxy-3-chloro)propyl-6-methoxyphenol Structure

91520-03-5

2-(2-acetoxy-3-...

~%

(8-methoxy-3,4-dihydro-2H-chromen-3-yl) acetate Structure

91520-04-6

(8-methoxy-3,4-...


Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved