Ultra-short-acting. beta.-adrenergic receptor blocking agents. 3. Ethylenediamine derivatives of (aryloxy) propanolamines having esters on the aryl function

…, WL Matier, RJ Gorczynski, WG Anderson

Index: Erhardt, Paul W.; Woo, Chi M.; Matier, William L.; Gorczynski, Richard J.; Anderson, William G. Journal of Medicinal Chemistry, 1983 , vol. 26, # 8 p. 1109 - 1112

Full Text: HTML

Citation Number: 23

Abstract

Ethylenediamine Derivatives of (Ary1oxy) propanolamines Journal of Medicinal Chemistry, 1983, Vol. 26, No. 8 1111 amides 8 and 9 or for the sulfamide 10. The primary ureas 11 and 12, although extremely potent, showed minimal cardioselectivity and possessed long durations of action. Alternatively, the phenyl-substituted urea 13 was found to have considerable cardioselectivity, approximately 25-fold as determined in vitro. This finding is ...