Tetrahedron Letters

An intramolecular Tsuji-Trost reaction based approach to the synthesis of 6-methylene indolizidines

RE Martin, ME Polomska, LT Byrne, SG Stewart

Index: Martin, Romy E.; Polomska, Marta E.; Byrne, Lindsay T.; Stewart, Scott G. Tetrahedron Letters, 2011 , vol. 52, # 38 p. 4878 - 4881

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Abstract

Abstract Herein we describe the efficient stereoselective preparation of C8 substituted indolizidines bearing a 6-methylene group, from the chiral pool starting material l-proline. This synthesis, employing a Tsuji-Trost reaction as the key step, represents a potentially, efficient route to pumiliotoxin natural product epimers.