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Preparation of azulenyllithium and magnesium reagents utilizing halogen–metal exchange reaction of several iodoazulenes with organolithium or magnesium ate …

…, Y Matsui, T Watanabe, A Ohta, K Fujimori, T Murafuji…

Index: Ito, Shunji; Kubo, Takahiro; Morita, Noboru; Matsui, Yoshitaka; Watanabe, Toshiyuki; Ohta, Akira; Fujimori, Kunihide; Murafuji, Toshihiro; Sugihara, Yoshikazu; Tajiri, Akio Tetrahedron Letters, 2004 , vol. 45, # 14 p. 2891 - 2894

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Citation Number: 45

Abstract

However, the halogen–metal exchange reaction with a metallic reagent is still unexplored in azulene itself. With the aim of developing a new facile method for the functionalization of azulene, we investigated the iodine–metal exchange reaction of iodoazulenes using n-butyllithium ( n BuLi) and lithium tri(n-butyl)magnesate ( n Bu 3 MgLi), which has been recently reported to induce a facile halogen–magnesium exchange reaction with various aryl halides. 5 ...