Cross??Coupling of Aryllithiums with Aryl and Vinyl Halides in Flow Microreactors

…, A Kenmoku, N Takabayashi, A Hayashi…

Index: Nagaki, Aiichiro; Moriwaki, Yuya; Haraki, Suguru; Kenmoku, Akira; Takabayashi, Naofumi; Hayashi, Atsushi; Yoshida, Jun-Ichi Chemistry - An Asian Journal, 2012 , vol. 7, # 5 p. 1061 - 1068

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Citation Number: 15

Abstract

Abstract The use of Pd catalysts that contained a carbene ligand, such as PEPPSI-SIPr, speeded up the Murahashi coupling of ArLi with ArBr, by enabling its integration with the Br/Li exchange of ArBr with BuLi in flow. Space integration realized the rapid cross-coupling of two different ArBr substrates. However, the cross-coupling reaction with vinyl halides could not be achieved under similar conditions. Pd (OAc) 2 was an effective catalyst, and ...