New method for C–H arylation/alkylation at α-position of cyclic aliphatic ethers by iron-oxide mediated reaction

…, U Singh, S Ambala, M Yadav, SD Sawant…

Index: Singh, Parvinder Pal; Gudup, Satish; Aruri, Hariprasad; Singh, Umed; Ambala, Srinivas; Yadav, Mahipal; Sawant, Sanghapal D.; Vishwakarma, Ram A. Organic and Biomolecular Chemistry, 2012 , vol. 10, # 8 p. 1587 - 1597

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Citation Number: 31

Abstract

We report a new and efficient iron oxide catalyzed cross-coupling reaction between organometallic species such as alkyl/arylmagnesium halides or organolithium species and α- hydrogen bearing cyclic unbranched and branched aliphatic ethers via activation of C (sp3)– H. In the presence of 1 mol% of iron oxide, five and six membered unbranched cyclic ethers such as tetrahydrofuran and tetrahydropyran gave good to excellent yields of cross- ...