… vivo evaluation of 3??[11C] methyl??(3??methoxy??naphthalen)??2??yl??(1??benzyl??piperidin)??4??yl??acetate (SB??235753), as a putative dopamine D4 receptors antagonist for …

M Matarrese, D Soloviev, RM Moresco…

Index: Matarrese; Soloviev; Moresco; Todde; Simonelli; Colombo; Magni; Carpinelli; Fazio; Kienle, M. Galli Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 4 p. 359 - 374

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Citation Number: 12

Abstract

The precursor for the radiosynthesis 3-hydroxynaphthyl-2-[N-benzyl)-piperidyl]-acetate hydrochloride was prepared by a four-step synthesis starting from ethyl-4-pyridyl acetate. The radiolabelling consisted of methylation with [ 11 C]methyltriflate in dimethylformamide in the presence of potassium hydroxide. [ 11 C]SB-235753, was synthesised in 30 min with a radiochemical yield of 10±5% (EOS, non-decay corrected) with 99% radiochemical purity and specific radioactivity of ...