Procaspase-3 activation as an anti-cancer strategy: structure− activity relationship of procaspase-activating compound 1 (PAC-1) and Its cellular co-localization with …

…, CJ Novotny, RK Totten, PJ Hergenrother

Index: Peterson, Quinn P.; Hsu, Danny C.; Goode, David R.; Novotny, Chris J.; Totten, Ryan K.; Hergenrother, Paul J. Journal of Medicinal Chemistry, 2009 , vol. 52, # 18 p. 5721 - 5731

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Citation Number: 99

Abstract

A goal of personalized medicine as applied to oncology is to identify compounds that exploit a defined molecular defect in a cancerous cell. A compound called procaspase-activating compound 1 (PAC-1) was reported that enhances the activity of procaspase-3 in vitro and induces apoptotic death in cancer cells in culture and in mouse xenograft models. Experimental evidence indicates that PAC-1 activates procaspase-3 in vitro through ...