Interaction of secondary amines with aromatic aldehydes-efficient method for synthesis of the functionalized heterocyclic amines

ZV Ignatovich, KN Gusak, TV Chernikhova…

Index: Ignatovich; Gusak; Chernikhova; Kozlov; Koroleva Chemistry of Heterocyclic Compounds, 2007 , vol. 43, # 12 p. 1540 - 1543

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Abstract

A method is proposed for the benzylation of secondary heterocyclic amines with functionalized derivatives of benzaldehyde in the presence of formic acid under conditions close to amination according to the Leuckart–Wallach reaction. ... Keywords: N-methylpiperazine, benzaldehyde derivatives, formic acid, pyrrolidine, reductive amination. ... The piperazine ring is a key structural fragment of a large group of compounds, the broad spectrum of activity of which explains ...