Design and synthesis of bis-carbamate analogs of cyclic bis-(3′-5′)-diguanylic acid (c-di-GMP) and the acyclic dimer PGPG

…, SR Jackson, W Deng, CLMJ Verlinde…

Index: Kline, Toni; Jackson, Stona R.; Deng, Wei; Verlinde, Christophe L. M. J.; Miller, Samuel I. Nucleosides, Nucleotides and Nucleic Acids, 2008 , vol. 27, # 12 p. 1282 - 1300

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Citation Number: 16

Abstract

The bacterial second messenger cyclic bis-(3′-5′)-diguanylic acid (c-di-GMP) regulates diverse Gram-negative bacterial virulence functions. The pathways that control, or are controlled by, c-di-GMP suggest that c-di-GMP signaling systems may encompass potential drug targets. It is presently undetermined, however, whether up-or down-modulation of c-di- GMP signaling would be the desired therapeutic state. We addressed potential drug target ...