e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Structure-cytoprotective activity relationship of simple molecules containing an α, β-unsaturated carbonyl system
AM Rodríguez, RD Enriz, LN Santagata…
Index: Rodriguez, Ana M.; Enriz, Ricardo D.; Santagata, Luis N.; Jauregui, Esteban A.; Pestchanker, Mauricio J.; Giordano, Oscar S. Journal of Medicinal Chemistry, 1997 , vol. 40, # 12 p. 1827 - 1834
In previous reports we attributed the cytoprotective activity of several sesquiterpene lactones to the presence of a nonhindered electrophilic acceptor in their structure. We suggested that the mechanism of protection would be, at least in part, mediated through a reaction between the electrophilic acceptor and the sulfhydryl-containing groups of the mucosa. We report here the gastric cytoprotective effect of simple molecules containing an α, β-unsaturated ...
