Tetrahedron letters

Amino protection using triazones

S Knapp, JJ Hale, M Bastos, FS Gibson

Index: Knapp, Spencer; Hale, Jeffrey J.; Bastos, Margarita; Gibson, Frank S. Tetrahedron Letters, 1990 , vol. 31, # 15 p. 2109 - 2112

Full Text: HTML

Citation Number: 43

Abstract

Abstract Primary amines protected by incorporation into a “triazone” derivative (3) are stable to various reduction, oxidation, organometallic, and basic hydrolysis conditions, and may be regenerated by treatment with aqueous ammonium chloride at 70. An application to polyamine synthesis is described.