Development of β-amino alcohol derivatives that inhibit Toll-like receptor 4 mediated inflammatory response as potential antiseptics

SA Chavez, AJ Martinko, C Lau, MN Pham…

Index: Chavez, Sherry A.; Martinko, Alexander J.; Lau, Corinna; Pham, Michael N.; Cheng, Kui; Bevan, Douglas E.; Mollnes, Tom E.; Yin, Hang Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4659 - 4669

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Citation Number: 15

Abstract

Toll-like receptor 4 (TLR4) induced proinflammatory signaling has been directly implicated in severe sepsis and represents an attractive therapeutic target. Herein, we report our investigations into the structure–activity relationship and preliminary drug metabolism/ pharmacokinetics study of β-amino alcohol derivatives that inhibit the TLR4 signaling pathway. Lead compounds were identified from in vitro cellular examination with ...