Preparation of intermediates for fluorinated lignans by conjugated and tandem additions on 3-fluorofuran-2 (5H)-one

…, R Vlasáková, J Plocar, O Paleta…

Index: Kvicala, Jaroslav; Vlasakova, Ruzena; Plocar, Jakub; Paleta, Oldrich; Pelter, Andrew Collection of Czechoslovak Chemical Communications, 2000 , vol. 65, # 5 p. 772 - 788

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Citation Number: 11

Abstract

Abstract Two syntheses of 3-fluorofuran-2 (5H)-one (1) based on Wittig-Horner reaction of ethyl (diethoxyphosphoryl) fluoroacetate (15) with 2-oxoethyl acetate (16) or on transformation of D-erythronolactone (10) are given. 3-Fluorofuran-2 (5H)-one (1) and ethyl 2-fluorobut-2-enoate (2) undergo conjugate addition with soft nucleophiles based on arene- carboxaldehyde dithioacetals 7 to form 2-fluorolactones 3 and 2-fluoroalkanoates 4. ...