β??Aryl Nitrile Construction via Palladium??Catalyzed Decarboxylative Benzylation of α??Cyano Aliphatic Carboxylate Salts

R Shang, Z Huang, X Xiao, X Lu…

Index: Shang, Rui; Huang, Zheng; Xiao, Xiao; Lu, Xi; Fu, Yao; Liu, Lei Advanced Synthesis and Catalysis, 2012 , vol. 354, # 13 p. 2465 - 2472,8

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Citation Number: 31

Abstract

Abstract The palladium-catalyzed decarboxylative benzylation of α-cyano aliphatic carboxylate salts with benzyl electrophiles was discovered. This reaction exhibits good functional group compatibility and proceeds under relatively mild conditions. A diverse range of quaternary, tertiary and secondary β-aryl nitriles can be conveniently prepared by this method.