N-[2-(2, 4-Difluorophenoxy) trifluoromethyl-3-pyridyl] sulfonamide derivatives 3—6 were prepared by the reaction of 3-pyridylamines and sulfonyl chlorides. Inhibitory activities of these compounds toward secretory phospholipase A 2 (sPLA 2) were examined and N-[2-(2, 4-difluorophenoxy)-5-trifluoromethyl-3-pyridyl]-2-naphthalenesulfonamide (5c) was found to be the most potent against sPLA 2 with an IC 50 value of 90 μM.
