Potential antiparkinsonic agents: Synthesis and pharmacology of some 4-fluoro-4'-halogen'benzhydryl 2-(N, N-disubstituted amino) ethyl ethers

Z Vejdělek, J Metyš, J Holubek, E Svátek…

Index: Vejdelek; Metys; Holubek; et al. Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 11 p. 2649 - 2660

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Citation Number: 2

Abstract

Abstract Reactions of 4, 4'-dihalogenated benzhydrols and 1, 1-diphenylethanols Xab and XIab with sodium hydride and 2-dimethylaminoethyl chloride and 2-pyrrolidinoethyl chloride afforded the ethers Vab-VIIIab. 2-Bromoethyl ethers IXab, obtained from the benzhydrols Xab and 2-bromoethanol by treatment with sulfuric acid, were subjected to substitution reactions with 4-phenylpiperidin-4-ol, 4-(2-tolyl) piperidin-4-ol (XVI), 4-(4-fluorophenyl) ...