Tetrahedron letters

Synthesis of α-chloroamides in water

AJ Harte, T Gunnlaugsson

Index: Harte, Andrew J.; Gunnlaugsson, Thorfinnur Tetrahedron Letters, 2006 , vol. 47, # 35 p. 6321 - 6324

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Citation Number: 34

Abstract

The reaction between chloroacetyl chloride and mono-or bis-aliphatic or aromatic amines in water under basic or neutral conditions gives rise to the formation of a variety of functionalized α-chloroamides. The resulting products were obtained as solids in moderate to good yields, upon precipitation and isolation by filtration.