Synthesis of 5-substituted benzyl-2, 4-diamino pyrimidine derivatives as c-Fms kinase inhibitors

…, W Sun, HY Liu, LL Wang, JH Xiao, XH Yang…

Index: Xu, Li Bao; Sun, Wei; Liu, Hong Ying; Wang, Li Li; Xiao, Jun Hai; Yang, Xiao Hong; Li, Song Chinese Chemical Letters, 2010 , vol. 21, # 11 p. 1318 - 1321

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Citation Number: 4

Abstract

A serials of novel 5-substituted benzyl-2, 4-diamino pyrimidine derivatives have been synthesized and evaluated as inhibitors of c-Fms kinase by the standard MTT method. The results showed that compound 15, 5-[3-methoxy-4-(pyridine-3-yl) benzyl]-2, 4-diamino pyrimidine, had an IC50 of 1.45 μmol/L in inhibiting the proliferation of M-CSF-dependent myeloid leukemia cells in mice (NFS-60), which was similar with GW2580, a selective ...