Synthesis of mandelic acid derived phthalimides as a new class of anti-inflammatory and antimicrobial agents

R Varala, V Kotra, MM Alam, NR Kumar…

Index: Varala, Ravi; Kotra, Vijay; Alam, M. Mujahid; Kumar, N. Ramesh; Ganapaty; Adapa, Srinivas R. Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2008 , vol. 47, # 8 p. 1243 - 1248

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Citation Number: 8

Abstract

In the present study, a new series of 2-(1, 3-dioxo-2, 3-dihydro-1H-2-isoindolyl) ethyl 2- hydroxy-2-(substituted phenyl) acetates 6a-e have been synthesized from the combination of N-(2-hydroxy ethyl) phthalimide 5 and substituted mandelic acids 2a-e which resulted in both anti-inflammatory and antimicrobial activity. These compounds have been characterized by IR, 1H NMR, mass spectral and elemental analysis. Among the ...