Urolithin as a converging scaffold linking ellagic acid and coumarin analogues: design of potent protein kinase CK2 inhibitors

…, A Gianoncelli, P Bonvini, E Zorzi, R Pasquale…

Index: Cozza, Giorgio; Gianoncelli, Alessandra; Bonvini, Paolo; Zorzi, Elisa; Pasquale, Riccardo; Rosolen, Angelo; Pinna, Lorenzo A.; Meggio, Flavio; Zagotto, Giuseppe; Moro, Stefano ChemMedChem, 2011 , vol. 6, # 12 p. 2273 - 2286

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Citation Number: 24

Abstract

Abstract Casein kinase 2 (CK2) is a ubiquitous, essential, and highly pleiotropic protein kinase; its abnormally high constitutive activity is suspected to underlie its pathogenic potential in neoplasia and other relevant diseases. Previously, using different in silico screening approaches, two potent and selective CK2 inhibitors were identified by our group: ellagic acid, a naturally occurring tannic acid derivative (K i= 20 n M) and 3, 8-dibromo-7- ...